Ranking, selecting, and prioritising genes with desirability functions

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Ranking, selecting, and prioritising genes with desirability functions

In functional genomics experiments, researchers often select genes to follow-up or validate from a long list of differentially expressed genes. Typically, sharp thresholds are used to bin genes into groups such as significant/non-significant or fold change above/below a cut-off value, and ad hoc criteria are also used such as favouring well-known genes. Binning, however, is inefficient and does...

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ژورنال

عنوان ژورنال: PeerJ

سال: 2015

ISSN: 2167-8359

DOI: 10.7717/peerj.1444